Glutaryl-CoA-dehydrogenase (GCDH) is a homotetrameric enzyme that catalyzes the conversion of glutaryl-CoA to crotonyl-CoA as part of the L-lysine and L-tryptophan metabolic pathway. Each monomer of the enzyme is rendered in a different color.
Lysine residues in monomer 4 (purple) that are subject to post-translational modification are highlighted in yellow and most of these appear to have important roles in the normal function of the protein. Hydrogen bonds are colored green and salt-bridge/electrostatic interactions are colored orange. Baking of the high poly surface was done in Marmoset. Renders were done in Marmoset except for those in the final published manuscript version, which were done in Lightwave 2018. Explicit solvent-based energy minimization of the crystal structure for human GCDH (PDB accession code 1SIR) provided the basis of the model.